Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC Vh4127 TFA | 1034.35 (free base) | 5 MG
VH4127 TFA is a cyclic peptide that targets the low-density lipoprotein receptor (LDLR) with a KD of 18 nM for human LDLR. It specifically binds to the rodent and human epidermal growth factor (EGF) homology domain of LDLR. It is intended for research use only.
- Targets the low density lipoprotein receptor (LDLR)
- High affinity with a KD of 18 nM for human LDLR
- Specifically binds to rodent and human epidermal growth factor (EGF) homology domain of LDLR
- Documentation: data sheet and handling instructions are available
- Formulation: supplied as a solid
- For research use only
Medchemexpress LLC Alpha-Melanocyte-Stimulating Hormone TFA | 171869-93-5 | 98.5% | 1 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide and a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities and is a post-translational derivative of pro-opiomelanocortin (POMC).
- Endogenous neuropeptide
- MC4R agonist with anti-inflammatory and antipyretic activities
- Post-translational derivative of pro-opiomelanocortin (POMC)
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells
- Modulates NFκB activation
- Inhibits translocation of transcription factor κB to the nucleus
Medchemexpress LLC Gln-AMS TFA | 99.85% | 588.47 | 50 MG
Gln-AMS (TFA) is a type Ia aminoacyl-tRNA synthetase (AARS) inhibitor. It specifically inhibits glutaminyl-tRNA synthetase (GlnRS) with a Ki of 1.32 μM. This product is intended for research use only.
- Inhibits glutaminyl-tRNA synthetase.
- High purity of 99.85%.
- Available in various quantities.
- Data sheet, COA, SDS, and handling instructions provided.
- Supported by customer reviews and publications.
Medchemexpress LLC RSM3 TFA | 98.83% | 3049.66 | 5 MG
RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with a Kd of 3.10 μM. It inhibits tumor growth and induces cell apoptosis. RSM3 TFA can be used for the study of cancer.
- Inhibits tumor growth
- Induces cell apoptosis
- Used for the study of cancer
- Stapled peptide
- METTL3-METTL14 inhibitor
Medchemexpress LLC L2P4 TFA | 98.3% | 1961.83 (free base) | 5 MG
L2P4 TFA is a peptide-based and EBNA1 targeting fluorescent probe. It inhibits EBNA1 homodimer formation and selectively inhibits EBV+ tumor growth. L2P4 TFA exhibits cytotoxicity in EBV-positive C666-1 cells with an LC50 of 46.4 μM.
- Peptide-based probe
- EBNA1 targeting
- Inhibits EBNA1 homodimer formation
- Selectively inhibits EBV+ tumor growth
- Exhibits cytotoxicity in EBV-positive C666-1 cells
- Suitable for cancer targeted therapy and immunotherapy research
- Used in peptide-drug conjugates research
Medchemexpress LLC HDAC11-IN-1 TFA | 99.3% | 995.15 | 1 MG
HDAC11-IN-1 TFA is a selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM. It exhibits good cell permeability and can inhibit the expression of YAP1 and SOX2. The product is for research purposes only and is not sold to patients.
- Selective macrocyclic inhibitor of HDAC11 with a Ki of 40 nM.
- Exhibits good cell permeability.
- Can inhibit the expression of YAP1 and SOX2.
- For research purposes only.
Medchemexpress LLC TL033 TFA | 2746343-70-2 | 98.1% | 1630.83 | 5 MG
TL033 TFA (HY-147340A) is a chemical compound with CAS number 2746343-70-2 and a molecular weight of 1630.83. This product is supplied as a light yellow to yellow solid with a high purity of 98.1% (HPLC). It requires specific storage conditions to maintain its integrity, ensuring reliability for research applications.
- CAS number: 2746343-70-2
- Purity (HPLC): 98.1%
- Molecular weight: 1630.83
- Appearance: Light yellow to yellow solid
- Recommended storage (solid): -20°C, sealed, away from moisture and light
- Storage in solvent: -80°C (6 months) or -20°C (1 month), sealed, away from moisture and light
Medchemexpress LLC Α-MSH (TFA) | 171869-93-5 | 98.5% | 25 MG
α-MSH TFA (α-Melanocyte-Stimulating Hormone TFA) is an endogenous neuropeptide that acts as a melanocortin receptor 4 (MC4R) agonist. It exhibits anti-inflammatory and antipyretic activities, being a post-translational derivative of pro-opiomelanocortin (POMC).
- Modulates CNS inflammation by acting directly on melanocortin receptors in glial cells.
- Modulates NFκB activation.
- Inhibits translocation of transcription factor κB to the nucleus.
- Effectively modulates inflammatory reactions when given systemically.
Medchemexpress LLC Iberiotoxin TFA | 99.4% | 4230.85 | 1 MG
Iberiotoxin (TFA) is a potent and selective inhibitor of high conductance Ca2+-activated K+ channels. This compound demonstrates high affinity for its target with a Kd of approximately 1 nM, and it specifically targets these channels without affecting other types of voltage-dependent ion channels.
- Selective inhibitor of high conductance Ca2+-activated K+ channels.
- High affinity with a Kd of ~1 nM.
- Does not block other types of voltage-dependent ion channels.
Medchemexpress LLC Lysylcysteine TFA | 97.8% | 477.38 | 25 MG
Lysylcysteine TFA (L-Lysyl-L-cysteine TFA) is a dipeptide composed of lysine and cysteine, intended for research use only. It is not for human use. This product is provided as a white to off-white solid with a high purity of 97.84% and a molecular weight of 477.38. It is shipped at room temperature in the continental US and requires sealed storage away from moisture.
- High purity: 97.84%
- Molecular weight: 477.38
- Dipeptide composed of lysine and cysteine
- Appearance: White to off-white solid
- Sequence: Lys-Cys
- Storage for powder: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Mambalgin 1 TFA | 95.72% | 6554.54 (free acid) | 500 UG
Mambalgin 1 TFA is a potent and selective inhibitor of ASIC1a. It exhibits IC50 values of 192 nM for human ASIC1a and 72 nM for ASIC1a/1b dimer, binding to closed/inactive channels. This compound demonstrates high selectivity for ASIC1a over a range of other channels including ASIC2a, ASIC3, TRPV1, P2X2, 5-HT3, Nav1.8, Cav3.2, and Kv1.2. Research indicates its ability to increase the latency of withdrawal response in mouse tail-flick and paw-flick tests.
- Selective ASIC1a inhibitor
- Binds to closed/inactive channels
- Increases latency of withdrawal response in mouse tail-flick and paw-flick tests
Medchemexpress LLC Ppack TFA | 157379-44-7 | 99.8% | 5 MG
PPACK TFA is a potent, selective, and irreversible thrombin inhibitor supplied as the trifluoroacetate (TFA) salt. It is used as an anticoagulant alternative for blood gas and whole-blood electrolyte analyses and inhibits plasminogen activator (rt-PA) binding to plasma protease inhibitors.
- Irreversible thrombin inhibitor for anticoagulant applications.
- Supplied as the trifluoroacetate salt for stability and handling.
- High analytical purity (99.8%).
- Suitable for blood gas and whole-blood electrolyte analyses.
- Available in a 5 mg research-size vial.
- CAS number: 157379-44-7.
Medchemexpress LLC NN1177 (TFA) | 98.7% | 4570.07 (free base) | 5 MG
NN1177 TFA (NNC9204-1177 TFA) is a long-acting GLP-1/glucagon receptor co-agonist. This compound is known to induce dose-dependent body weight loss in diet-induced obese mice and improves glucose tolerance. It has also been shown to reduce liver fat and relevant inflammatory and fibrosis biomarkers in NASH models.
- Long-acting GLP-1/glucagon receptor co-agonist
- Induces body weight loss
- Improves glucose tolerance
- Reduces liver fat
- Reduces inflammatory and fibrosis relevant biomarkers
- For research use only
Medchemexpress LLC Ql9 tfa | 95.91% | 5 MG
QL9 (QLSPFPFDL) TFA is a high-affinity alloantigen for the 2C T cell receptor (TCR), intended for research use only.
- High-affinity alloantigen
- Specific for the 2C T cell receptor (TCR)
- Suitable for research applications